ea0020p520 | Paediatric Endocrinology | ECE2009
Passeri Elena
, Ermetici Federica
, Carminati Massimo
, Costa Elena
, Fugazzola Laura
, Persani Luca
, Ambrosi Bruno
, Corbetta Sabrina
Congenital hypothyroidism is frequently associated with congenital cardiac malformations (CCM). Studies in knock-out mice showed that heart and great vessels organogenesis share some nuclear transcription factors with the embryonic thyroid, suggesting that thyroid defects may have a higher prevalence in children with CCM. The present study investigated thyroid function and morphology in 280 children (145 M/135 F, aged 0.312 years), affected by CCM (septal defects, ductus...